Deborah F Smith Selected Research

glycylpeptide N-tetradecanoyltransferase

6/2016	Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.
10/2014	Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.
7/2014	Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.
1/2012	Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
4/2010	N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
3/2010	N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.

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Deborah F Smith Research Topics

Disease

9	Infections 01/2012 - 02/2003
4	Visceral Leishmaniasis (Kala Azar) 05/2017 - 10/2003
4	Leishmaniasis 05/2017 - 09/2010
3	African Trypanosomiasis (Nagana) 06/2016 - 04/2010
2	Parasitic Diseases (Parasitic Disease) 07/2014 - 02/2003
2	Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl) 02/2013 - 07/2012
1	Ciliopathies 02/2013
1	Inborn Genetic Diseases (Disease, Hereditary) 07/2012
1	Cicatrix (Scar) 01/2012
1	Cutaneous Leishmaniasis 03/2011
1	Trypanosomiasis 04/2010
1	Granuloma 03/2010
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 05/2005
1	Communicable Diseases (Infectious Diseases) 10/2003
1	Acquired Immunodeficiency Syndrome (AIDS) 02/2003
1	Malaria 02/2003
1	Mycoses (Diseases, Fungus) 02/2003

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 06/2016 - 02/2003
6	glycylpeptide N-tetradecanoyltransferaseIBA 06/2016 - 03/2010
4	VaccinesIBA 05/2017 - 10/2003
4	Pharmaceutical PreparationsIBA 06/2016 - 02/2003
3	EnzymesIBA 06/2016 - 02/2003
3	Monomeric GTP-Binding ProteinsIBA 02/2013 - 01/2012
3	AntigensIBA 03/2010 - 01/2006
2	Toll-Like Receptors (Toll-Like Receptor)IBA 09/2004 - 04/2004
2	Complement System Proteins (Complement)IBA 11/2003 - 10/2003
1	Myristic Acid (Tetradecanoic Acid)IBA 06/2016
1	Serine C-PalmitoyltransferaseIBA 01/2012
1	SNARE Proteins (SNAREs)IBA 01/2012
1	Immune Sera (Antisera)IBA 09/2010
1	Peptides (Polypeptides)IBA 03/2010
1	RNA (Ribonucleic Acid)IBA 07/2009
1	Interleukin-10 (Interleukin 10)IBA 07/2006
1	ChemokinesIBA 09/2004
1	Chemokine CCL5IBA 09/2004
1	Toll-Like Receptor 4IBA 04/2004
1	AntibodiesIBA 10/2003
1	TransferasesIBA 02/2003

Therapy/Procedure

2	Therapeutics 03/2012 - 02/2003
1	Drug Therapy (Chemotherapy) 05/2017